Deterministic approaches (TER, HQ) for standard and higher tier assessments:
Comparison of predicted exposure levels with endpoints from laboratory, extended laboratory, micro- and mesocosm and other semi-field and field tests
Generic refinements as agreed by the competent authority (national specific)
Refinements of exposure levels with regard to more realistic conditions and / or implementation of risk mitigation measures, choice of focal species (e.g. birds / mammal risk assessment), weight-of-evidence approaches on the relevance of endpoints, recolonisation / recovery of treated areas and affected species
Refinement of trigger values (e.g. reduction of uncertainty factors in view of higher tier data or an extended data base with lower tier endpoints)
Probabilistic approaches, such as species sensitivity distribution (SSD-plots) and related probabilistic risk assessments
Expert judgment on qualitative endpoints from field studies
Assessment on the biological activity of metabolites
At all stages of the risk assessments:
Evaluation and critical review of the existing data base
Identification (and monitoring) of appropriate studies